Researchers at Cardiff University have uncovered how a particularly severe form of DNA damage arises—shedding new light on mutation processes that contribute to cancer and inherited genetic conditions ...

A study explains how broken DNA during cell division can trigger chromoanasynthesis when two repair pathways combine, causing erratic copying and large DNA duplications, offering potential targets for ...

An estimated 170,000 Australians were diagnosed with cancer in 2025. Many people know the causes of cancer are partly genetic. But how do your genes, which contribute so much of what makes you you, ...

Houston Methodist scientists have uncovered an unexpected side of a protein best known for its link to brain diseases. The ...

Cardiff University researchers discovered how a particularly severe type of DNA damage occurs, giving fresh insight into mutation mechanisms that contribute to cancer and inherited genetic diseases.

While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that ...

Despite the significance of immune checkpoint inhibitors (ICIs) in solid tumor treatment, identifying ICI-sensitive populations remains a challenge. Mutations in DNA damage response (DDR) pathway ...

DNA polymerase epsilon catalytic subunit A (POLE) gene plays a crucial role in DNA repair and chromosomal replication. Mutations in the POLE gene have ...

In a step toward treating mitochondrial diseases, researchers in the Netherlands have successfully edited harmful mutations in mitochondrial DNA using a genetic tool known as a base editor. The ...

The Amazon molly is an evolutionary enigma: an all-female fish that reproduces by cloning itself. Because it doesn’t mix its DNA with a mate’s, Darwinian logic holds that harmful mutations should pile ...