The proinflammatory cytokines, interleukin-1β (IL-1β), tumor necrosis factor α (TNFα), and interferon γ (IFNγ), are cytotoxic to pancreatic islet β cells, possibly by inducing nitric oxide and/or ...

The mechanisms of peroxynitrite-induced apoptosis are not fully understood. We report here that peroxynitrite-induced apoptosis of PC12 cells requires the simultaneous activation of p38 and JNK MAP ...

This new article publication from Acta Pharmaceutica Sinica B, discusses mitochondria-specific near-infrared photoactivation of peroxynitrite upconversion luminescent nanogenerator for precision ...

The repeated use of opiate drugs such as morphine to relieve chronic pain results in individuals having to take higher and higher doses of the drug to achieve equivalent pain relief (they are said to ...