Background Pharmacotherapy combinations have been shown to improve survival and reduce hospitalisations in adults with ...

Anticoagulation is a critical component in the treatment of cardiovascular diseases. Large randomised controlled trials have ...

Background The epidemiology and long-term healthcare utilisation associated with chronic kidney disease (CKD) among those ...

Cardiovascular disease (CVD) remains one of the leading causes of mortality in England, with its burden disproportionately ...

The global pandemics of plague and smallpox in the Middle Ages claimed hundreds of millions of lives. In this era, long before the concepts of pathogens and infectious diseases were established, ...

Atrial fibrillation (AF) is a common arrhythmia associated with increased risk of stroke, heart failure and mortality. Advances in genomic research have revealed a complex genetic architecture ...

Original research: Off-label underdosing of edoxaban antithrombotic therapy for patients with atrial fibrillation and stable coronary artery disease: findings from the EPIC-CAD trial (9 September, ...

Objective Severe secondary tricuspid regurgitation (STR) causes significant right atrial (RA) volume overload, resulting in structural and functional RA-remodelling. This study evaluated whether ...

The systematic review and meta-analysis recently published in Heart provides the most comprehensive synthesis to date of the survival benefit associated with guideline-directed medical therapy (GDMT) ...

Atrial fibrillation (AF) is the most common arrhythmia and is a leading cause of stroke and heart failure yet often remains undiagnosed. Screening has been proposed to identify asymptomatic AF and ...

In the early 2000s, the natural history of heart failure (HF) was vividly illustrated, highlighting a defining feature of HF progression: a prolonged course of fluctuating yet steadily worsening ...

Objective To determine the individual variability in the response to aspirin and/or clopidogrel and its impact on graft patency after off-pump coronary artery bypass grafting. Design A single-centre ...